妊娠糖尿病与产前产后心理障碍之间的因果关联：两项样本孟德尔随机化研究的证据

Gestational diabetes mellitus (GDM) is associated with multiple maternal and neonatal complications, but its direct causal impact on peripartum mental health remains uncertain. This study used a two-sample Mendelian randomization (MR) approach to assess whether genetically predicted GDM increases the risk of peripartum mental disorders, including depression, anxiety, and suicidality. Genetic variants associated with GDM were obtained from the FinnGen consortium, and summary data for peripartum mental disorders were derived from genome-wide association studies. Independent single-nucleotide pol