产前可卡因暴露会改变新生大鼠海马CA1区锥形神经元的突触可塑性。

Prenatal cocaine exposure (PCE) severely affects brain development, psychology, and behavior in exposed offspring, while altering their susceptibility to drug addiction. however, the mechanisms underlying PCE-induced changes in cocaine-conditioned place preference (CPP) remain unclear. This study demonstrates that PCE attenuates cocaine-induced CPP, a process involving spatial memory and drug reward. We also investigated the dorsal hippocampus (dH), which is closely associated with spatial memory, and the ventral hippocampus (vH), which is linked to motivational reward mechanisms. Results indi