孕期阿片类镇痛药暴露与心理健康障碍对不良出生结局的独立及联合关联研究。

Opioid use, depression and anxiety during pregnancy are independently associated with adverse perinatal outcomes, but their joint associations are less understood. To examine the independent and joint associations, including interaction, of prenatal opioid analgesic exposure and maternal anxiety and depression with gestational age, preterm birth and birthweight-for-gestational-age percentile. We conducted a retrospective cohort study of 230,810 Wisconsin Medicaid singleton live births (2011-2019), linking Medicaid with birth record data. Multivariable regression models adjusted for maternal so