潜在类别分析可能预测对阿米替林有反应的肠易激综合症患者：来自ATLANTIS的事后分析。

Low-dose amitriptyline was superior to placebo for irritable bowel syndrome (IBS) in the ATLANTIS trial. We performed post hoc analyses of ATLANTIS to assess whether combinations of gastrointestinal and psychological symptoms influenced response to amitriptyline. We used latent class analysis (LCA) to subtype participants in ATLANTIS into clusters using both gastrointestinal and psychological symptoms. We assessed differences in response rates with amitriptyline, compared with placebo, by cluster, using mean difference in IBS Severity Scoring System (IBS-SSS) and multivariate odds ratios (ORs)