精神分裂症中脑内侧隔区的转录组改变

Schizophrenia (SZ) is associated with transcriptome alterations in the dorsolateral prefrontal cortex (dlPFC) and anterior cingulate cortex (ACC), key regions in a distributed network that mediates cognitive functions impaired in the illness. The subcortical dorsal claustrum (dCLA) is structurally densely interconnected with the ACC and dlPFC and functionally coactivated with these regions during certain cognitive tasks. To identify SZ-associated transcriptome alterations in the dCLA. This case-control study used RNA sequencing data for dCLA homogenates from postmortem human brain of individua