昼夜皮质醇、感知睡眠质量、活动性睡眠和抑郁：头颈癌患者的探索性试点

Background In patients with head and neck cancer (HNC), perceived sleep quality, actigraphy-derived sleep parameters, depressive symptoms, and diurnal cortisol may represent related behavioral and biological processes. This exploratory study tested a priori associations among these constructs. Methods Forty patients with HNC completed the Pittsburgh Sleep Quality Index (PSQI) and Patient Health Questionnaire-9 (PHQ-9), wore wrist actigraphs, and collected salivary cortisol at waking and bedtime across a 6-day period. Separate linear regressions tested associations of PSQI scores with actigraph