成人抑郁症患者的夜班工作和心血管疾病事件跨基线风险状况：英国生物库研究

Objective: To evaluate whether night-shift work is associated with incident cardiovascular disease (CVD) across baseline CVD risk profiles among adults with depression. Methods: In this prospective cohort study, we analyzed 52,565 UK Biobank participants with baseline depression. Night-shift work was identified from baseline and employment-history data. Cox models estimated adjusted hazard ratios (aHRs) across low-, intermediate-, and high-risk profiles. Results: Of 52,565 participants, 25,360 had a history of night-shift work. Compared with participants without night-shift work, those with ni