精神分裂症的控制限假说

Over the last half century, we have made little progress in the treatment of schizophrenia. A key contributor to this is an insufficient understanding of what is causing the disorder. There are currently two broad families of hypotheses: those focused on a dopaminergic dysfunction, and those focused on a glutamatergic dysfunction. Based on recent findings that antipsychotic drugs exhibit cell-type specific and long-term effects on cortical circuit function, we integrate the two hypotheses into what we call the control limit hypothesis of schizophrenia. It builds on the assumption that schizoph