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跨诊断疾病意识与否认模型:疾病洞察力这一更广泛概念的核心组成部分。

A transdiagnostic model of illness awareness and denial: Core components of the broader construct of insight into illness.
Gerretsen P、Song J、Shah P · Neuroscience and biobehavioral reviews · 2026-11-04

研究信息

期刊 / 来源
Neuroscience and biobehavioral reviews
发表日期
2026-11-04
文献库
PubMed
作者
Gerretsen P, Song J, Shah P
DOI
10.1016/j.neubiorev.2026.107081
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英文原文摘要全文

Insight into illness is a dynamic multidimensional construct that varies between individuals and medical and psychiatric disorders, and influences treatment engagement and clinical outcomes. Despite extensive study, accounts remain fragmented and disorder specific. This review focuses on subjective illness awareness and proposes a hypothesis-generating neurobiological framework in which fluctuations in awareness and denial emerge from interactions among self-representational networks, hierarchical predictive processing, and salience-threat systems that shape the balance between self-model stab

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