夜urnal恐惧的架构：发现恶梦相关基因的网络药理学方法

Nightmares impose a substantial burden on mental health, yet their molecular determinants remain poorly understood. We employed a network pharmacology approach to identify shared protein targets of structurally diverse nightmare-inducing drugs. This approach revealed an eight-protein interactome: serotonergic (HTR2A, HTR2C, HTR1A, HTR6, HTR7), dopaminergic (DRD2, DRD3), and the potassium channel KCNH2. Protein-protein interaction networks and Gene Ontology analysis identified DRD2, HTR1A, and HTR2A as central hubs. These genes showed enrichment for neurotransmitter receptor activity and synapt