Depressive Symptoms and Central Obesity Over the Menopausal Transition and the Development of Type 2 Diabetes Later in Life: Decomposing Direct and Indirect Effects.

This study investigated the association between depressive symptoms during the menopausal transition and subsequent incident type 2 diabetes (T2D), with particular focus on: (1) quantifying the mediating role of central obesity in this association, and (2) examining differential effects by depressive symptom subscales (somatic vs. cognitive/affective symptoms). We analyzed data from 1719 participants in the Study of Women's Health Across the Nation, a multi-ethnic cohort study of midlife women. Depressive symptoms were assessed repeatedly using the Center for Epidemiologic Studies Depression S