[Differential diagnosis of rheumatoid arthritis pain: the role of subjective DAS28 scores, joint ultrasound, and digital biomarkers in therapeutic decision-making].

The purpose of this review is to examine the diagnostic challenges arising from the mathematical biases of the DAS28 index used in monitoring rheumatoid arthritis, as well as the psychological and neurobiological factors underlying patient-physician discordance. Furthermore, this paper aims to analyze the role of digital biomarkers in future decision-making. A structural characteristic of the DAS28 index is that its subjective components carry twice the weight of objective metrics. In cases of central sensitization, depression, or anxiety, this can result in "false-positive" disease activity,