迷幻蘑菇素调节伏隔核活动

Abstract Psilocybin is a serotonergic hallucinogen that acts primarily through 5-HT₂A receptor signaling, yet the mechanisms by which it regulates mesolimbic inhibitory tone remain poorly understood. Here we investigated how psilocybin and structurally related synthetic tryptamines modulate inhibitory signaling in the nucleus accumbens (NAc) and whether astrocyte-associated mechanisms contribute to this process. Psilocybin-like tryptamines that generalized to the psilocybin cue increased NAc neuronal activity while reducing extracellular GABA levels, identifying diminished NAc GABAergic tone a