较低的血浆多巴胺β-羟化酶水平与英国生物银行中的自杀死亡率相关

Objective: Suicide remains a major global public health concern, yet its biological underpinnings remain incompletely understood at the population level.Although monoaminergic dysregulation has been implicated in suicidal behavior, population-based studies directly examining circulating proteomic profiles in suicide mortality remain limited.Methods: We conducted an exploratory, population-based case-control study as a secondary analysis of existing UK Biobank plasma proteomic data generated with the Olink proximity extension assay, comparing 22 individuals who subsequently died by suicide with