创伤后应激障碍和药物使用障碍合并症的抑郁负担和差异治疗效果：来自Project Harmony的调查结果

Background: Depression commonly co-occurs with posttraumatic stress disorder (PTSD) and substance use disorders (SUDs), yet it remains unclear whether depression meaningfully alters treatment response for individuals with PTSD/SUD. Prior studies have examined depression as an individual predictor with mixed findings but no studies to date have evaluated depression’s moderating role across a broad range of PTSD/SUD treatment modalities using harmonised individual patient data (IPD).Objective: To determine whether baseline depression moderates within- and post-treatment changes in PTSD symptom s