Research digest · 研究速递

接受HAIC联合免疫治疗和靶向治疗的肝细胞癌患者的睡眠障碍和相关因素：一项横断面研究

Sleep Disturbance and Associated Factors in Hepatocellular Carcinoma Patients Receiving HAIC Combined with Immunotherapy and Targeted Therapy: A Cross-Sectional Study

Yanxia Huang、Shuyue Liu、Tiantian Wang · Cancer Management and Research · 2026-10-31

目的：本研究评估了肝细胞癌（HCC）患者接受肝动脉灌注化疗（HAIC）联合靶向治疗和免疫治疗的睡眠障碍患病率及相关因素。

研究信息

期刊 / 来源: Cancer Management and Research
发表日期: 2026-10-31
文献库: OpenAlex
作者: Yanxia Huang, Shuyue Liu, Tiantian Wang
DOI: 10.2147/cmar.s648657

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英文原文摘要全文

Purpose: This study assessed the prevalence of sleep disturbance and associated factors in patients with hepatocellular carcinoma (HCC) receiving hepatic arterial infusion chemotherapy (HAIC) combined with targeted therapy and immunotherapy. Patients and Methods: A cross-sectional survey enrolled 230 patients undergoing HAIC combined with targeted therapy and immunotherapy at Sun Yat-sen University Cancer Center (July–November 2025). Sleep, psychological distress, pain, appetite, and quality of life were assessed using the PSQI, HADS, NRS, VAS, and EORTC QLQ-C30, respectively, along with prior

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这条研究涉及的词条

经典实验

习得性无助

反复经历无法控制的负面刺激后，个体会停止尝试——即使后来有了改变处境的机会。

情绪与压力

杏仁核与恐惧学习

杏仁核是威胁探测与恐惧条件化的关键节点，它快而粗，可以在意识之前启动反应。

情绪与压力

HPA 轴与皮质醇

下丘脑—垂体—肾上腺这条轴是身体应对压力的主回路，终点是皮质醇的释放。

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