关于Suresh等人（2026）的研究评论

Suresh et al. (2026, Psychopharmacology) related GloVe embeddings of 4,496 first-hand reports of 21 psychedelic drugs to receptor affinity profiles using partial least squares regression (PLSR), and reported associations between specific receptors and experiential themes. Because affinities vary only between drugs, every report of a drug carries the same profile. I show algebraically that within-drug variation drops out of every cross-product with the affinities. The published loadings can be reproduced from the drug means alone (r ≥ 0.998), so the analysis rests on 21 drugs, with a Kish effec