Pain in rare disorders.

Rare disorders collectively affect more than 300 million people worldwide and often require lifelong multidisciplinary care. Although pain is not universal, it is a clinically important and frequently underrecognized manifestation in many rare disorders, contributing to impaired functioning, psychological distress, reduced participation and quality of life, and caregiver burden. Assessment and management are complicated by heterogeneous pain mechanisms, limited disease-specific evidence, fragmented care pathways, and a lack of standardized guidance. This Perspective proposes a clinically orien