Beyond headache frequency: How acute treatment response shapes migraine-related disability-Insights from a joint stratification framework: A cross-sectional study.

The aim of this study was to examine whether joint profiling of headache frequency and acute treatment response identifies clinically meaningful patient subgroups with different disability burden and treatment needs, and whether per-attack acute treatment response provides disability-relevant information beyond monthly headache days and other measured covariates. Headache frequency guides migraine treatment escalation, yet the quality of acute treatment response may represent an equally important but underassessed determinant of disability. This cross-sectional study enrolled 404 consecutive p