致幻剂调节兴奋-抑制平衡与情感核心自我的机制

Abstract Serotonergic psychedelics reliably alter affective tone, emotional regulation, and self-experience. Prevailing theories emphasize acute changes in neural entropy, default mode network integrity, and large-scale functional connectivity but do not offer a clear mechanism that explains how 5-HT2A receptor pharmacology relates to lasting changes in affect and self-related processing. This article addresses this gap by proposing a testable mechanistic framework in which serotonergic modulation of excitation–inhibition (E-I) balance functions across a hierarchical regulatory architecture of