尼古丁代谢与睡眠行为关系的基因组研究

BACKGROUND AND AIMS: Increased nicotine exposure (resulting from greater cigarette consumption and/or slower nicotine metabolism) may directly affect sleep and could underlie relationships between smoking and sleep behaviours identified previously. We conducted a Mendelian randomisation (MR) study to explore whether nicotine metabolism has a causal effect on sleep behaviours. DESIGN: Our main analysis method was inverse-variance weighted (IVW) Multivariable MR, which was used to examine the independent effects of nicotine metabolism and smoking heaviness on sleep behaviours. The model was deve