Gut-Brain coherence: a new therapeutic strategy for stress-related tumor.

Chronic psychological stress significantly exacerbates tumor initiation, progression, and metastasis through neuroendocrine dysregulation and tumor-associated immunosuppression. Beyond direct neural pathways, stress is increasingly recognized as a driver of gut microbiota dysbiosis, which triggers systemic or local metabolic reprogramming, and fosters a suppressive tumor immune microenvironment. Understanding the complex interplay between chronic stress and oncogenic process offers critical insights into the underlying mechanisms of cancer biology. The microbiota-gut-brain axis (MGBA), as the